RESUMO
U.S. plan would harness the "RNome" for medicine and more-but funding is uncertain.
Assuntos
Financiamento de Capital , RNA , Análise de Sequência de RNA , Análise de Sequência de RNA/economia , Projeto Genoma Humano/economia , Estados Unidos , Humanos , Vacinas de mRNA/genética , RNA/genética , RNA/metabolismo , DoençaAssuntos
População Negra/genética , Genoma Humano/genética , Genômica , Análise de Sequência de DNA , África/etnologia , Anemia Falciforme/genética , Genômica/economia , Genômica/organização & administração , Objetivos , Perda Auditiva/genética , Projeto Genoma Humano/economia , Humanos , Análise de Sequência de DNA/economiaRESUMO
The HGP-write project, announced in 2016 but not really implemented yet, comes back as a project aimed at constructing an "ultra-safe" human cell line fully resistant to virus infection and with other desirable characteristics. This involves introducing 400,000 changes in the genome and raises a number of technical and financial issues, but may become realistic in mid-term.
Assuntos
Projeto Genoma Humano , Redação , Escherichia coli/genética , Genoma Humano/fisiologia , Projeto Genoma Humano/economia , Projeto Genoma Humano/organização & administração , Humanos , Anotação de Sequência Molecular/economia , Anotação de Sequência Molecular/métodos , Editoração/economia , Editoração/organização & administraçãoRESUMO
The recently proposed « HGP-write ¼ project aims to synthetize a full human genome and to introduce it into cells. This ambitious endeavour is fraught with financial and technical uncertainties and, if successful, would make « synthetic humans ¼ a definite possibility even though this is not part of its announced goals. Accordingly, it has not been received with enthusiasm.
Assuntos
DNA/biossíntese , Genoma Humano , Custos e Análise de Custo , Projeto Genoma Humano/economia , Humanos , Análise de Sequência de DNAAssuntos
Farmacogenética/história , Medicina de Precisão/história , Alcaptonúria/genética , Arsenitos/efeitos adversos , Arsenitos/história , Arsenitos/uso terapêutico , Tipagem e Reações Cruzadas Sanguíneas/história , Transfusão de Sangue/história , Transfusão de Sangue/métodos , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/genética , Classificação , Sistema Enzimático do Citocromo P-450/genética , Sistema Enzimático do Citocromo P-450/metabolismo , Feminino , Testes Genéticos/história , Terapia Genética/história , Genética/história , Genoma Humano/genética , Genótipo , Grécia , História do Século XVIII , História do Século XIX , História do Século XX , História do Século XXI , História Antiga , Projeto Genoma Humano/economia , Projeto Genoma Humano/história , Humanos , Anamnese , Ayurveda/história , Feniltioureia/farmacologia , Compostos de Potássio/efeitos adversos , Compostos de Potássio/história , Compostos de Potássio/uso terapêutico , Análise de Sequência de DNA/economia , Análise de Sequência de DNA/história , Análise de Sequência de DNA/instrumentação , Paladar/efeitos dos fármacos , Paladar/genética , Varfarina/efeitos adversosRESUMO
The 22 Arab nations have a unique genetic structure, which reflects both conserved and diverse gene pools due to the prevalent endogamous and consanguineous marriage culture and the long history of admixture among different ethnic subcultures descended from the Asian, European, and African continents. Human genome sequencing has enabled large-scale genomic studies of different populations and has become a powerful tool for studying disease predictions and diagnosis. Despite the importance of the Arab genome for better understanding the dynamics of the human genome, discovering rare genetic variations, and studying early human migration out of Africa, it is poorly represented in human genome databases, such as HapMap and the 1000 Genomes Project. In this review, I demonstrate the significance of sequencing the Arab genome and setting an Arab genome reference(s) for better understanding the molecular pathogenesis of genetic diseases, discovering novel/rare variants, and identifying a meaningful genotype-phenotype correlation for complex diseases.
Assuntos
Árabes/genética , Genoma Humano , Projeto HapMap/economia , Projeto Genoma Humano/economia , HumanosRESUMO
Three recent and very large projects aim to integrate several "omics" approaches in order to promote pro-active medicine and to create a "Wellness industry".
Assuntos
Projeto Genoma Humano , Longevidade/genética , Academias e Institutos/economia , California , Genótipo , Saúde , Setor de Assistência à Saúde/economia , Setor de Assistência à Saúde/organização & administração , Projeto Genoma Humano/economia , Projeto Genoma Humano/organização & administração , Humanos , FenótipoAssuntos
Redução de Custos , Genômica/economia , Genômica/métodos , Organização do Financiamento/economia , Genoma Humano/genética , Genômica/tendências , Projeto Genoma Humano/economia , Humanos , Nanotecnologia/economia , Nanotecnologia/métodos , National Human Genome Research Institute (U.S.)/economia , Análise de Sequência de DNA/economia , Análise de Sequência de DNA/métodos , Análise de Sequência de DNA/tendências , Estados UnidosRESUMO
The 4th Biennial Meeting of the Human Variome Project Consortium was held at the headquarters of the United Nations Educational, Scientific and Cultural Organization (UNESCO) in Paris, 11-15 June 2012. The Human Variome Project, a nongovernmental organization and an official partner of UNESCO, enables the routine collection, curation, interpretation, and sharing of information on all human genetic variation. This meeting was attended by more than 180 delegates from 39 countries and continued the theme of addressing issues of implementation in this unique project. The meeting was structured around the four main themes of the Human Variome Project strategic plan, "Project Roadmap 2012-2016": setting normative function, behaving ethically, sharing knowledge, and building capacity. During the meeting, the members held extensive discussions to formulate an action plan in the key areas of the Human Variome Project. The actions agreed on were promulgated at the Project's two Advisory Council and Scientific Advisory Committee postconference meetings.
Assuntos
Variação Genética , Projeto Genoma Humano , China , Bases de Dados Genéticas , Educação Profissionalizante/organização & administração , Educação Profissionalizante/tendências , Organização do Financiamento , Projeto Genoma Humano/economia , Projeto Genoma Humano/ética , Humanos , Fenótipo , Nações UnidasRESUMO
The Human Variome Project (http://www.humanvariomeproject.org) is an international effort aiming to systematically collect and share information on all human genetic variation. The two main pillars of this effort are gene/disease-specific databases and a network of Human Variome Project Country Nodes. The latter are nationwide efforts to document the genomic variation reported within a specific population. The development and successful operation of the Human Variome Project Country Nodes are of utmost importance to the success of Human Variome Project's aims and goals because they not only allow the genetic burden of disease to be quantified in different countries, but also provide diagnosticians and researchers access to an up-to-date resource that will assist them in their daily clinical practice and biomedical research, respectively. Here, we report the discussions and recommendations that resulted from the inaugural meeting of the International Confederation of Countries Advisory Council, held on 12th December 2011, during the 2011 Human Variome Project Beijing Meeting. We discuss the steps necessary to maximize the impact of the Country Node effort for developing regional and country-specific clinical genetics resources and summarize a few well-coordinated genetic data collection initiatives that would serve as paradigms for similar projects.
